Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

@article{Berton2006EssentialRO,
  title={Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress},
  author={Olivier Berton and Colleen A. McClung and Ralph J. DiLeone and Vaishnav Krishnan and William Renthal and Scott J. Russo and Danielle L. Graham and Nadia M. Tsankova and Carlos A. Bola{\~n}os and Maribel Rios and Lisa M. Monteggia and David W Self and Eric J. Nestler},
  journal={Science},
  year={2006},
  volume={311},
  pages={864 - 868}
}
Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of… 
View on AAAS
usdbiology.com
1,775 Citations
Highly Influential Citations
116
Background Citations
665
Methods Citations
194
Results Citations
76

1,775 Citations

Citation Type

Citation Type

Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress–Induced Depressive Behaviors
Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
TLDR
It is reported that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens of socially stressed mice but not of stress-naive mice, unraveling a stress context–detecting function of the brain's mesolimbic circuit.
Viral depletion of VTA BDNF in rats modulates social behavior, consequences of intermittent social defeat stress, and long-term weight regulation
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
TLDR
It is found that the transcription factor ΔFosB mediates an essential mechanism of resilience in mice, and establishes a previously unknown molecular pathway underlying both resilience and antidepressant action.
BDNF Signaling in the VTA Links the Drug-Dependent State to Drug Withdrawal Aversions
TLDR
Chronic opiate administration activates BDNF-related neuronal plasticity in the VTA that is necessary for both the establishment of an opiate-dependent state and aversive withdrawal motivation, highlighting the importance of a bivalent, plastic mechanism that drives the negative reinforcement underlying addiction.
Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system
TLDR
It is found that acute SDS increased DYN mRNA levels within the nucleus accumbens, a key element of brain dopamine (DA) systems, and that KORs expressed in DA systems regulate the effects of acute, but not chronic, social stress.
Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward
TLDR
BDNF-oxytocin interactions in the brain are implicated in mammalian maternal behavior and BDNF gene expression is increased in the hippocampus of rat mothers that show increased pup licking/grooming and oxytocin-induced regulation of BDNF in the nucleus accumbens provides a neuroendocrine basis for both individual differences in maternal Behavior and resilience to the stress of reproduction in female mammals.
Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress
Short- and long-term effects of intermittent social defeat stress on brain-derived neurotrophic factor expression in mesocorticolimbic brain regions
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
Enhancement of Locomotor Activity and Conditioned Reward to Cocaine by Brain-Derived Neurotrophic Factor
TLDR
The profound effects of BDNF on the enhancement of both cocaine-induced locomotion and facilitation of CR are demonstrated and a possible role for BDNF in long-term adaptations of the brain to cocaine is suggested.
Social isolation after a single defeat reduces striatal dopamine transporter binding in rats
TLDR
It is concluded that social isolation after a single defeat reduces the number of DAT binding sites, and suggests that housing conditions are critical when investigating the central nervous effects of social defeat in male rats.
BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization
TLDR
It is shown that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens both during development and in adulthood, and may be an important determinant of pathophysiological conditions such as drug addiction, schizophrenia or Parkinson's disease.
Long-term effects of social stress on brain and behavior: a focus on hippocampal functioning
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
TLDR
Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods, and these changes were observed during tests for sucrose craving.
Long-term behavioral and neuronal cross-sensitization to amphetamine induced by repeated brief social defeat stress: Fos in the ventral tegmental area and amygdala
Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization
TLDR
It is shown that PI3K is required for the expression, but not the induction, of behavioral sensitization to cocaine in rats, an animal model of the long-lasting functional changes induced by repeated drug use.
Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study
Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta
TLDR
Brain-derived neurotrophic factor depletion from the MHB selectively leads to reduced TH expression in a subpopulation of neurons, but it remains unclear whether these cells are lost.
...
1
2
3
4
...