Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

@article{Berton2006EssentialRO,
  title={Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress},
  author={Olivier Berton and Colleen A. McClung and Ralph J. DiLeone and Vaishnav Krishnan and William Renthal and Scott J. Russo and Danielle L. Graham and Nadia M. Tsankova and Carlos A. Bola{\~n}os and Maribel Rios and Lisa M. Monteggia and David W Self and Eric J. Nestler},
  journal={Science},
  year={2006},
  volume={311},
  pages={864 - 868}
}
Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of… 
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