Essential Role for the P55 Tumor Necrosis Factor Receptor in Regulating Hematopoiesis at a Stem Cell Level

Abstract

Hematopoietic stem cell (HSC) self-renewal is a complicated process, and its regulatory mechanisms are poorly understood. Previous studies have identified tumor necrosis factor (TNF)-alpha as a pleiotropic cytokine, which, among other actions, prevents various hematopoietic progenitor cells from proliferating and differentiating in vitro. However, its role… (More)

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Cite this paper

@article{Rebel1999EssentialRF, title={Essential Role for the P55 Tumor Necrosis Factor Receptor in Regulating Hematopoiesis at a Stem Cell Level}, author={Vivienne I. Rebel and Sheila Hartnett and Geoffrey R Hill and Suzan B. Lazo-Kallanian and James Ferrara and Colin A. Sieff}, journal={The Journal of Experimental Medicine}, year={1999}, volume={190}, pages={1493 - 1504} }