Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior


The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits. These excitatory, nonselective cationic channels are regulated by G protein, phospholipase C-coupled receptors. Here, we show that TRPC5(-/-) mice exhibit diminished innate fear levels… (More)
DOI: 10.1016/j.cell.2009.03.039


Cite this paper

@article{Riccio2009EssentialRF, title={Essential Role for TRPC5 in Amygdala Function and Fear-Related Behavior}, author={Antonio Riccio and Yan Li and Jisook Moon and Kwangsoo Kim and Kiersten S. Smith and Uwe Rudolph and Svetlana Gapon and Gui Lan Yao and Evgeny Tsvetkov and Scott J. Rodig and Ashlee Van't Veer and Edward G. Meloni and William A. Carlezon and Vadim Y. Bolshakov and David E Clapham}, journal={Cell}, year={2009}, volume={137}, pages={761-772} }