Essential Immunoregulatory Role for BCAP in B Cell Development and Function

@article{Yamazaki2002EssentialIR,
  title={Essential Immunoregulatory Role for BCAP in B Cell Development and Function},
  author={Tetsuo Yamazaki and Kiyoshi Takeda and Kumiko Gotoh and Hiroshi Takeshima and Shizuo Akira and Tomohiro Kurosaki},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={535 - 545}
}
BCAP was recently cloned as a binding molecule to phosphoinositide 3-kinase (PI3K). To investigate the role of BCAP, mutant mice deficient in BCAP were generated. While BCAP-deficient mice are viable, they have decreased numbers of mature B cells and B1 B cell deficiency. The mice produce lower titers of serum immunoglobulin (Ig)M and IgG3, and mount attenuated responses to T cell--independent type II antigen. Upon B cell receptor cross-linking, BCAP-deficient B cells exhibit reduced Ca(2… CONTINUE READING