Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

@article{Jou2002EssentialNR,
  title={Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.},
  author={S J Jou and Nick Carpino and Yutaka Takahashi and Roland P. Piekorz and Jyh-Rong Chao and Neena Carpino and Demin Wang and James N. Ihle},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 24},
  pages={8580-91}
}
Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3-kinases (PI3Ks). To assess the role of the delta isoform of the p110 catalytic subunit of PI3Ks, we derived enzyme-deficient mice. The mice are viable but have decreased numbers of mature B cells, a block in pro-B-cell differentiation, and a B1 B-cell deficiency. Both immunoglobulin M receptor-induced Ca(2+) flux and proliferation in response to B-cell mitogens are attenuated. Immunoglobulin levels are decreased… CONTINUE READING