Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo

@article{Loomis2003EspinCC,
  title={Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo},
  author={Patricia A. Loomis and Lili Zheng and Gabriella Sekerkov{\'a} and Benjarat Changyaleket and Enrico Mugnaini and James R. Bartles},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={163},
  pages={1045 - 1055}
}
The espin actin-bundling proteins, which are the target of the jerker deafness mutation, caused a dramatic, concentration-dependent lengthening of LLC-PK1-CL4 cell microvilli and their parallel actin bundles. Espin level was also positively correlated with stereocilium length in hair cells. Villin, but not fascin or fimbrin, also produced noticeable lengthening. The espin COOH-terminal peptide, which contains the actin-bundling module, was necessary and sufficient for lengthening. Lengthening… CONTINUE READING