EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7.

@article{Ritchie2008EspFUAT,
  title={EspFU, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7.},
  author={Jennifer M. Ritchie and Michael John Brady and Kathleen N. Riley and Theresa Deland Ho and Kenneth G Campellone and Ira M. Herman and Arthur Donohue-Rolfe and Saul Tzipori and Matthew K Waldor and John M Leong},
  journal={Cellular microbiology},
  year={2008},
  volume={10 4},
  pages={836-47}
}
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 induces filamentous actin-rich 'pedestals' on intestinal epithelial cells. Pedestal formation in vitro requires translocation of bacterial effectors into the host cell, including Tir, an EHEC receptor, and EspF(U), which increases the efficiency of actin assembly initiated by Tir. While inactivation of espF(U) does not alter colonization in two reservoir hosts, we utilized two disease models to explore the significance of EspF(U)-promoted actin… CONTINUE READING

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