Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing.

@article{Baatar2002EsophagealUT,
  title={Esophageal ulceration triggers expression of hypoxia-inducible factor-1 alpha and activates vascular endothelial growth factor gene: implications for angiogenesis and ulcer healing.},
  author={Dolgor Baatar and Michael K. Jones and Koji Tsugawa and Rama Pai and Woo Sung Moon and Gou Young Koh and Injune Kim and Seigo Kitano and Andrzej S. Tarnawski},
  journal={The American journal of pathology},
  year={2002},
  volume={161 4},
  pages={1449-57}
}
Our previous studies demonstrated that enhanced epithelial cell proliferation is important for healing of experimental esophageal ulcers. However, the roles of angiogenesis, its major mediator, vascular endothelial growth factor (VEGF), and the mechanism(s) regulating VEGF expression during esophageal ulcer healing remain unknown. Esophageal ulcers were… CONTINUE READING