Esophageal mucosal eicosanoids in gastroesophageal reflux disease and Barrett's esophagus.

@article{Triadafilopoulos1996EsophagealME,
  title={Esophageal mucosal eicosanoids in gastroesophageal reflux disease and Barrett's esophagus.},
  author={George Triadafilopoulos and M Kaczynska and Masataka Iwane},
  journal={The American journal of gastroenterology},
  year={1996},
  volume={91 1},
  pages={
          65-74
        }
}
OBJECTIVE Eicosanoids (prostaglandins and leukotrienes) may contribute to the clinical manifestations of gastroesophageal reflux disease (GERD). In this cross-sectional study, our purpose was to assess the role of leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in the clinical, endoscopic, and histological manifestations of GERD. METHODS Using RIA, we measured ex vivo LTB4 and PGE2 content in esophageal mucosal biopsies from 141 patients with or without gastroesophageal reflux disease who… CONTINUE READING

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