Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis.


OBJECTIVE To evaluate esophageal body motor contractions occurring during esophageal reflux in pediatric patients with gastro-esophageal reflux disease (GERD). METHODS Patients referred for the evaluation of GERD who were evaluated with combined 24-hour pH probe and esophageal manometry test (MP24) were included. Patients were separated into the following groups: Group C -- normal pH probe and normal EGD; Group 1 -- abnormal pH probe and normal EGD; and Group 2 -- abnormal pH probe and EGD with histologic esophagitis. Esophageal motor function during reflux episodes was analyzed. RESULTS Twenty-five patients were included. All had a normal stationary esophageal manometry. Patients in Groups 1 and 2 had significantly more gastroesophageal reflux by pH probe than Group C (P < 0.01). During the MP24, patients in Group 1 and 2 had significantly fewer contractions per minute pre-, during, and post-GER (P < 0.05). There were significant differences in the number of isolated and prolonged contractions (>7 sec) during prolonged GERD episodes >5 minutes (P < 0.05). CONCLUSION Children with GERD have a decreased number and abnormal esophageal body contractions with esophageal reflux. This suggests that children with GERD with and without esophagitis have impaired esophageal body acid clearance.

Citations per Year

408 Citations

Semantic Scholar estimates that this publication has 408 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Chitkara2005EsophagealMA, title={Esophageal motor activity in children with gastro-esophageal reflux disease and esophagitis.}, author={Denesh K. Chitkara and Christine K Fortunato and Samuel Nurko}, journal={Journal of pediatric gastroenterology and nutrition}, year={2005}, volume={40 1}, pages={70-5} }