Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure.

@article{Chang2020EsophagealCC,
  title={Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure.},
  author={Zhiheng Chang and T. Dang and Na Che and Hui Yu and Jian-yuan Chai and Weichang Chen},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2020}
}
  • Zhiheng Chang, T. Dang, +3 authors Weichang Chen
  • Published 2020
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • BACKGROUND TRAIL is best known for killing cancer cells selectively, however, some cancers resist TRAIL treatment for various reasons. Esophageal adenocarcinoma is such an example. Previously, we reported that the tumor cells interrupted TRAIL-mediated apoptosis by overexpressing the decoy receptors and survivin. AIMS To investigate TRAIL resistance in esophageal adenocarcinoma during GERD. METHODS We simulated GERD episodes in vitro by exposing cancer cells to the acid/bile conditions… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 21 REFERENCES
    Regulation of NF-κB by TNF family cytokines.
    • 269
    • Open Access
    Death receptors as targets in cancer
    • 133
    • Open Access
    Systems biology of death receptor networks: live and let die
    • 55
    • Open Access