Esomeprazole reduces gastric and duodenal ulcer development among high risk NSAID users

@article{Scheiman2003EsomeprazoleRG,
  title={Esomeprazole reduces gastric and duodenal ulcer development among high risk NSAID users},
  author={James M. Scheiman and Neville D Yeomans and Christopher J. Hawkey and Nicholas J Talley and Ludwig Wilhelm Gothe and J Sung and Robert Hillary Boucaut Jones and J. Naesdal},
  journal={American Journal of Gastroenterology},
  year={2003},
  volume={98},
  pages={S52-S52}
}
Purpose: The prevalence of gastric (GU) or duodenal ulcers (DU) in NSAID users is 10–30% and ulcer development is highly dependent on intragastric pH. This double-blind, parallel-group, multicenter study evaluated the effect of esomeprazole over 6 months compared with placebo for ulcer prevention, in high risk patients receiving daily NSAID therapy. Methods: We studied 585 H. pylori-negative patients ( 18 y), who had taken non-selective or COX-2 selective NSAIDs for 4 weeks. The patients had no… CONTINUE READING