Esomeprazole provides improved acid control vs. omeprazole In patients with symptoms of gastro-oesophageal reflux disease.

@article{Lind2000EsomeprazolePI,
  title={Esomeprazole provides improved acid control vs. omeprazole In patients with symptoms of gastro-oesophageal reflux disease.},
  author={Tore Lind and Lars Rydberg and A Kyleb{\"a}ck and A J{\'o}nsson and Tommy Andersson and G{\"o}ran S Hasselgren and Johan Holmberg and Kerstin R{\"o}hss},
  journal={Alimentary pharmacology & therapeutics},
  year={2000},
  volume={14 7},
  pages={861-7}
}
BACKGROUND Esomeprazole (Nexium) is a new proton pump inhibitor for the treatment of acid-related diseases. METHODS In this double-blind crossover study, 38 patients with gastro-oesophageal reflux disease (GERD) symptoms were randomized to esomeprazole 40 and 20 mg and omeprazole 20 mg once daily for 5 days. On day 5 of each dosing period, 24-h intragastric pH and pharmacokinetic variables were measured. RESULTS Thirty-six patients aged 29-58 (mean 45) years completed the study… CONTINUE READING

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