Esomeprazole Compared With Famotidine in the Prevention of Upper Gastrointestinal Bleeding in Patients With Acute Coronary Syndrome or Myocardial Infarction

@article{Ng2012EsomeprazoleCW,
  title={Esomeprazole Compared With Famotidine in the Prevention of Upper Gastrointestinal Bleeding in Patients With Acute Coronary Syndrome or Myocardial Infarction},
  author={Fook-Hong Ng and Prabowo Tunggal and Wai-Ming Chu and Kwok-fai Lam and Andrew John Li and Kit Nga Chan and Yuk-kong Lau and Carolyn Poey Lyn Kng and K K Keung and Ambrose Chi-Pong Kwan and Benjamin Chun-yu Wong},
  journal={The American Journal of Gastroenterology},
  year={2012},
  volume={107},
  pages={389-396}
}
OBJECTIVES:Little is known about the efficacy of proton pump inhibitors compared with H2 receptor antagonists in preventing adverse upper gastrointestinal complications in patients with acute coronary syndrome (ACS) or ST elevation myocardial infarction (STEMI) receiving aspirin, clopidogrel, and enoxaparin or thrombolytics. The objective of this study was to compare the efficacies of esomeprazole and famotidine in preventing gastrointestinal complications.METHODS:A double-blind, randomized… CONTINUE READING
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Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial

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