Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway.

@article{Baek2015EsculetinAR,
  title={Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway.},
  author={J. Baek and Sun-Hyang Park and Yoon-Hee Cheon and Sung-Jun Ahn and Myeung-Su Lee and Jaemin Oh and Ju-Young Kim},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={461 2},
  pages={
          334-41
        }
}
Esculetin exerts various biological effects on anti-oxidation, anti-tumors, and anti-inflammation. However, the involvement of esculetin in the bone metabolism process, particularly osteoclast differentiation has not yet been investigated. In the present study, we first confirmed the inhibitory effect of esculetin on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation. We then revealed the relationship between esculetin and the expression of osteoclast-specific… Expand
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