Escitalopram: a unique mechanism of action.

  title={Escitalopram: a unique mechanism of action.},
  author={Claus Br{\ae}strup and Connie S{\'a}nchez},
  journal={International journal of psychiatry in clinical practice},
  volume={8 Suppl 1},
The 5-HT (5-hydroxytryptamine, serotonin) transporter (SERT) mediates the reuptake of 5-HT from the synaptic cleft into the neuron, and inhibition of this uptake is the target of selective serotonin reuptake inhibitors (SSRIs). Escitalopram (S-citalopram) is the most selective SSRI available, whereas the other enantiomer, R-citalopram, is approximately 30-40 times less potent than the S-enantiomer. Both biochemical experiments (measurement of extracellular 5-HT in the frontal cortex of rats… CONTINUE READING


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