Escherichia coli resistance to β-lactam antibiotics through a decrease in the affinity of a target for lethality

@article{Spratt1978EscherichiaCR,
  title={Escherichia coli resistance to β-lactam antibiotics through a decrease in the affinity of a target for lethality},
  author={Brian G. Spratt},
  journal={Nature},
  year={1978},
  volume={274},
  pages={713-715}
}
CLINICAL isolates of bacteria that have gained resistance to β-lactam antibiotics (penicillins, cephalosporins and related compounds) often arise by the acquisition of a plasmid that produces a β-lactamase1,2. An increase in β-lactamase activity has also been shown to cause resistance in some mutants isolated in the laboratory3. In other cases, β-lactamase… CONTINUE READING