Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase.

@article{Clark1980EscherichiaCM,
  title={Escherichia coli mutants with altered control of alcohol dehydrogenase and nitrate reductase.},
  author={David P. Clark and John E. Cronan},
  journal={Journal of bacteriology},
  year={1980},
  volume={141 1},
  pages={
          177-83
        }
}
Mutants of Escherichia coli which overproduce alcohol dehydrogenase were obtained by selection for the ability to use ethanol as an acetate source in a strain auxotrophic for acetate. A mutant having a 20-fold overproduction of alcohol dehydrogenase was able to use ethanol only to fulfill its acetate requirement, whereas two mutants with a 60-fold overproduction were able to use ethanol as a sole carbon source. The latter two mutants produced only 25% of the wild-type level of nitrate reductase… CONTINUE READING

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