Escherichia coli mutants temperature-sensitive for DNA synthesis


A series of mutants of E. coli temperature-sensitive for DNA synthesis has been studied. The temperature-sensitive DNA mutations map in seven distinct genetic loci most of which have not been previously reported. Mutations in dnaA and in dnaC affect the initiation of DNA replication; those at the remaining loci affect chain elongation. A temperature-sensitive F′lac is shown to suppress a group A mutant with somewhat less efficiency than other F′ factors previously reported by others. The gene products rendered temperaturesensitive by the mutations have not been identified for any of the loci.

DOI: 10.1007/BF00339547

12 Figures and Tables


Citations per Year

444 Citations

Semantic Scholar estimates that this publication has 444 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Wechsler1971EscherichiaCM, title={Escherichia coli mutants temperature-sensitive for DNA synthesis}, author={James A. Wechsler and Julian David Gross}, journal={Molecular and General Genetics MGG}, year={1971}, volume={113}, pages={273-284} }