Escherichia coli exports cyclic AMP via TolC.

  title={Escherichia coli exports cyclic AMP via TolC.},
  author={Klaus Hantke and Karin Winkler and Joachim E Schultz},
  journal={Journal of bacteriology},
  volume={193 5},
In Escherichia coli more than 180 genes are regulated by the cyclic AMP (cAMP)-cAMP receptor protein (CRP) complex. However, more than 90% of cAMP that is made by intracellular adenylyl cyclases is found in the culture medium. How is cAMP exported from E. coli? In a tolC mutant, 0.03 mM IPTG (isopropyl-β-d-thiogalactopyranoside) was sufficient to induce… CONTINUE READING