Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.

@article{Zhang2008EscherichiaCC,
  title={Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.},
  author={Weiping Zhang and Donald C. Robertson and Chengxian Zhang and Wei Bai and Mojun Zhao and David H. Francis},
  journal={Applied and environmental microbiology},
  year={2008},
  volume={74 18},
  pages={5832-7}
}
To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins. 

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Progress in enteric vaccine development

A. M. Svennerholm, D. Steels
Best Pract. Res. Clin. Gastroenterol • 2004

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