Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.

@article{Watanabe2009EscherichiaCA,
  title={Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.},
  author={Kenji Watanabe and Kinya Hotta and Mino Nakaya and Alex P Praseuth and Clay Chia Chun Wang and Daiki Inada and Kosaku Takahashi and Eri Fukushi and Hiroki Oguri and Hideaki Oikawa},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 26},
  pages={9347-53}
}
Natural products display impressive activities against a wide range of targets, including viruses, microbes, and tumors. However, their clinical use is hampered frequently by their scarcity and undesirable toxicity. Not only can engineering Escherichia coli for plasmid-based pharmacophore biosynthesis offer alternative means of simple and easily scalable production of valuable yet hard-to-obtain compounds, but also carries a potential for providing a straightforward and efficient means of… CONTINUE READING