Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.

@article{Delgado2001EscherichiaCR,
  title={Escherichia coli RNA polymerase is the target of the cyclopeptide antibiotic microcin J25.},
  author={M. A. Tarilonte Delgado and Mar{\'i}a Regina Rintoul and Ricardo N. Far{\'i}as and Ra{\'u}l Armando Salom{\'o}n},
  journal={Journal of bacteriology},
  year={2001},
  volume={183 15},
  pages={
          4543-50
        }
}
Escherichia coli microcin J25 (MccJ25) is a plasmid-encoded, cyclic peptide antibiotic consisting of 21 unmodified amino acid residues. It is primarily active on gram-negative bacteria related to the producer strain, inducing cell filamentation in an SOS-independent way. A mutation causing resistance to MccJ25 was isolated. Genetic analysis indicated that it resided in the rpoC gene, encoding the beta' subunit of RNA polymerase, at 90 min on the E. coli genetic map. The mutation was genetically… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 35 CITATIONS, ESTIMATED 50% COVERAGE

74 Citations

05'03'06'10'14'18
Citations per Year
Semantic Scholar estimates that this publication has 74 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Sequence analysis of the four plasmid genes required to produce the circular peptide antibiotic microcin J25

  • J. O. Solbiati, M. Ciaccio, R. N. Farı́as, E. González-Pastor, F. Moreno, R. A. Salomón
  • J. Bacteriol
  • 1999
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…