Escherichia coli EAST1 toxin toxicity of variants 17-2 and O 42.

@article{Veilleux2008EscherichiaCE,
  title={Escherichia coli EAST1 toxin toxicity of variants 17-2 and O 42.},
  author={Sophie Veilleux and Natalee Holt and Bruce D. Schultz and Jean Daniel Dubreuil},
  journal={Comparative immunology, microbiology and infectious diseases},
  year={2008},
  volume={31 6},
  pages={
          567-78
        }
}

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TLDR
This review summarizes the various observations on EAST1 since its discovery and proposes as a virulence factor implicated in the mechanism of pathogenesis of EAEC and could play a role in the pathogenicity of other enteropathogens as well.
Enteroaggregative Escherichia coli heat-stable enterotoxin 1 represents another subfamily of E. coli heat-stable toxin.
TLDR
It is predicted that EAST1 stimulates the particulate form of guanylate cyclase through the same receptor-binding region as STa and guanylin, a mammalian analog of STa.
Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model.
TLDR
It is indicated that strain 17-2 produces a low molecular weight, partially heat-stable, protease-sensitive enterotoxin which appears to be plasmid associated, and genetically and immunologically distinct from E. coli STa.
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The current state of the knowledge on the presence and probable role of EAST1 in farm animal diseases is reviewed and discussed.
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TLDR
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TLDR
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TLDR
Comparison of the EAST1 gene sequences analyzed in this study as well as those reported previously showed that EAggEC, EPEC, type 1 DA EC, type 2 DAEC, and enterotoxigenic E. coli shared a common sequence.
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TLDR
The gene encoding EAST1 is more broadly distributed among diarrheogenic E. coli than previously known and may represent an additional determinant in the pathogenesis of E. Escherichia coli diarrhea.
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