Escape-related behaviours in an unstable elevated and exposed environment I. A new behavioural model of extreme anxiety

@article{King1998EscaperelatedBI,
  title={Escape-related behaviours in an unstable elevated and exposed environment I. A new behavioural model of extreme anxiety},
  author={Sheila M. King},
  journal={Behavioural Brain Research},
  year={1998},
  volume={98},
  pages={113-126}
}
  • S. M. King
  • Published 1 December 1998
  • Psychology, Biology
  • Behavioural Brain Research
Free versus forced exposure to an elevated plus-maze: evidence for new behavioral interpretations during test and retest
TLDR
The results confirm that open-arm avoidance is a natural tendency and therefore that it is not learned during initial exposure to the maze, and contradict the hypothesis that there is acquisition of a phobic-like response to open arms during trial 1.
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents
TLDR
The unstable elevated exposed plus maze (UEEPM) may represent a paradigm to facilitate investigation into the neurochemical basis of extreme anxiety disorders and pharmacological similarities exist between symptoms of panic and anxiety in patients and escape from the UEEPM in rats.
Behavioral profile of wild mice in the elevated plus-maze test for anxiety
Further evidence for the predictive validity of the unstable elevated exposed plus-maze, a behavioural model of extreme anxiety in rats: Differential effects of fluoxetine and chlordiazepoxide
TLDR
It is suggested that the unstable elevated exposed plus-maze may represent a paradigm to facilitate investigation into the neurochemical basis of extreme anxiety disorders and support the pharmacological similarity between symptoms of panic in humans and escape in the UEEPM.
Further evidence for the predictive validity of the unstable elevated exposed plus-maze, a behavioural model of extreme anxiety in rats: Di¡erential e¡ects of £uoxetine and chlordiazepoxide
TLDR
The results further support the pharmacological similarity between symptoms of panic in humans and escape in the UEEPM and suggest that theUEEPM may represent a paradigm to facilitate investigation into the neurochemical basis of extreme anxiety disorders.
A comparison between Dark Agouti and Sprague-Dawley rats in their behaviour on the elevated plus-maze, open-field apparatus and activity meters, and their response to diazepam
TLDR
While the high level of anxiety-like behaviour of DA rats versus SD rats could prove useful in future ethological studies on anxiety, the fact that acute handling decreased the anxiety- like behaviour on the elevated plus maze may limit the value of this strain for the study of putative anxiolytic drugs.
5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze
TLDR
The results suggest that the escape-related behaviours exhibited by animals in the UEEPM are mediated, at least in part, by activation of the 5-HT2C receptor subtype.
Tests of unconditioned anxiety — Pitfalls and disappointments
  • A. Ennaceur
  • Psychology, Biology
    Physiology & Behavior
  • 2014
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