Escape of the response to a long-acting somatostatin analogue (SMS 201-995) in patients with VIPoma.

@article{Koelz1987EscapeOT,
  title={Escape of the response to a long-acting somatostatin analogue (SMS 201-995) in patients with VIPoma.},
  author={Annemarie Koelz and Marius Kraenzlin and Klaus Gyr and Volker Meier and Stephen R. Bloom and Philipp U. Heitz and Hans Stalder},
  journal={Gastroenterology},
  year={1987},
  volume={92 2},
  pages={527-31}
}
Two patients with severe secretory diarrhea due to metastatic vasoactive intestinal peptidoma were treated with a synthetic somatostatin analogue in an attempt to control the patients' vasoactive intestinal peptide-related symptoms. In both patients, a good initial response to this treatment could be demonstrated; not only did diarrhea subside but there was also a dramatic fall in vasoactive intestinal peptide plasma levels. However, after 11 and 4 days respectively, diarrhea recurred… CONTINUE READING