Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells

  title={Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells},
  author={H. Hisaeda and Yoichi Maekawa and Daiji Iwakawa and Hiroko Okada and K. Himeno and K. Kishihara and S. Tsukumo and K. Yasutomo},
  journal={Nature Medicine},
  • H. Hisaeda, Yoichi Maekawa, +5 authors K. Yasutomo
  • Published 2004
  • Biology, Medicine
  • Nature Medicine
  • Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4+CD25+ regulatory T cells (Treg) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of Treg cells contributes to immune suppression… CONTINUE READING
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