Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake

@article{Cnops2014EscapeMO,
  title={Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake},
  author={Jennifer Cnops and Stefan Magez and Carl De Trez},
  journal={Parasitology},
  year={2014},
  volume={142},
  pages={417 - 427}
}
SUMMARY African trypanosomes have been around for more than 100 million years, and have adapted to survival in a very wide host range. While various indigenous African mammalian host species display a tolerant phenotype towards this parasitic infection, and hence serve as perpetual reservoirs, many commercially important livestock species are highly disease susceptible. When considering humans, they too display a highly sensitive disease progression phenotype for infections with Trypanosoma… 
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References

SHOWING 1-10 OF 139 REFERENCES
African trypanosomes: the genome and adaptations for immune evasion.
TLDR
The African trypanosome Trypanosoma brucei is a flagellated unicellular parasite transmitted by tsetse flies that causes African sleeping sickness in sub-Saharan Africa and has developed an extremely sophisticated strategy of antigenic variation of its VSG coat allowing it to evade host antibodies.
Human African trypanosomiasis: clinical presentation and immune response
TLDR
The impact of dysregulated inflammatory responses in both systemic and CNS pathology will be examined and the potential for host genotype variation in disease severity and control will be discussed.
Interactions between trypanosomes and tsetse flies.
Evolution of the primate trypanolytic factor APOL1
TLDR
This study shows that both genetic variants of human APOL1 that protect against T. brucei rhodesiense have recapitulated molecular signatures found in Old World monkeys and raises the possibility that APol1 variants have broader innate immune activity that extends beyond trypanosomes.
Mechanism of Trypanosoma brucei gambiense resistance to human serum
TLDR
TbHpHbR inactivation preventing high APOL1 loading in hypohaptoglobinaemic serum may have evolved because of the overlapping endemic area of T. gambiense infection and malaria.
African Trypanosomes: Intracellular Trafficking of Host Defense Molecules 1
TLDR
Findings indicate that the cellular distribution of TLF is influenced by SRA expression and may directly determine susceptibility to T. b.
Chronic Trypanosoma congolense infections in mice cause a sustained disruption of the B‐cell homeostasis in the bone marrow and spleen
TLDR
It is shown that early on, an irreversible depletion of all developmental B cells stages occur in T. congolense trypanosomosis, and later‐stage infection‐induced IgGs were largely nonspecific, in particular in the more virulent TRT55 infection model.
The molecular arms race between African trypanosomes and humans
Humans can survive bloodstream infection by African trypanosomes, owing to the activity of serum complexes that have efficient trypanosome-killing ability. The two trypanosome subspecies that are
Modulation of innate immunity by African Trypanosomes
TLDR
Overall it appears that trypanosomes have carefully orchestrated the host innate and adaptive immune response so that parasite survival and transmission, and alterations of host immunity, are to its ultimate benefit.
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