Escape from crossover interference increases with maternal age

@article{Campbell2014EscapeFC,
  title={Escape from crossover interference increases with maternal age},
  author={Christopher L. Campbell and Nicholas A. Furlotte and Nick Eriksson and David A. Hinds and Adam Auton},
  journal={Nature Communications},
  year={2014},
  volume={6}
}
Recombination plays a fundamental role in meiosis, ensuring the proper segregation of chromosomes and contributing to genetic diversity by generating novel combinations of alleles. Here, we use data derived from direct-to-consumer genetic testing to investigate patterns of recombination in over 4,200 families. Our analysis reveals a number of sex differences in the distribution of recombination. We find the fraction of male events occurring within hotspots to be 4.6% higher than for females. We… 

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Meiotic Recombination: The Essence of Heredity.

  • N. Hunter
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2015
This review highlights the features of meiotic recombination that distinguish it from recombinational repair in somatic cells, and how the molecular processes of meiotics recombination are embedded and interdependent with the chromosome structures that characterize meiotic prophase.

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...

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