Escape from crossover interference increases with maternal age

  title={Escape from crossover interference increases with maternal age},
  author={Christopher L. Campbell and Nicholas A. Furlotte and Nick Eriksson and David A. Hinds and Adam Auton},
  journal={Nature Communications},
Recombination plays a fundamental role in meiosis, ensuring the proper segregation of chromosomes and contributing to genetic diversity by generating novel combinations of alleles. Here, we use data derived from direct-to-consumer genetic testing to investigate patterns of recombination in over 4,200 families. Our analysis reveals a number of sex differences in the distribution of recombination. We find the fraction of male events occurring within hotspots to be 4.6% higher than for females. We… 

Genetic Background, Maternal Age, and Interaction Effects Mediate Rates of Crossing Over in Drosophila melanogaster Females

The hypothesis that maternal age influences rates of crossing over in a genotypic-specific manner is tested and a new role of genotype by maternal age interactions in mediating recombination rate is revealed.

Crossover Interference, Crossover Maturation, and Human Aneuploidy.

Modern advances in the understanding of crossing over and CO interference are reviewed, the implications of human female CO maturation inefficiency are further discussed, and areas of interest for future studies are suggested.

Landscaping Crossover Interference Across a Genome.

Effect of sex, age and genetics on crossover interference in cattle

Large-scale analysis of Holstein and Jersey cattle with genotype data provided a comprehensive description of crossover interference across chromosome, sex and age groups, identified associated candidate genes, and produced useful insights into the mechanism ofrossover interference.

Meiotic Recombination: The Essence of Heredity.

  • N. Hunter
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2015
This review highlights the features of meiotic recombination that distinguish it from recombinational repair in somatic cells, and how the molecular processes of meiotics recombination are embedded and interdependent with the chromosome structures that characterize meiotic prophase.

Meiotic recombination hotspots - a comparative view.

Methodologies to profile hotspots at different steps of the meiotic recombination pathway that have been used in different eukaryote species are reviewed and what these studies have revealed concerning specification of hotspot locations and activity are discussed.

Per-nucleus crossover covariation is regulated by chromosome organization

“Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”

This work generates genome-wide maps of crossovers and chromosome segregation patterns by recovering all three products of single female meioses, and uncovers a new reverse chromosome segregation pattern in which both homologs separate their sister chromatids at meiosis I.

The rate of meiotic gene conversion varies by sex and age

A disproportionate number of NCO gene conversions in older mothers occur outside double-strand break regions and in regions with relatively low GC content, which points to age-related changes in the mechanisms of meiotic gene conversion in oocytes.



Recombination rate and reproductive success in humans

This work examined genome-wide microsatellite data for 23,066 individuals, providing information on recombination events of 14,140 maternal and paternal meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age.

High-Resolution Mapping of Crossovers Reveals Extensive Variation in Fine-Scale Recombination Patterns Among Humans

Dense, genome-wide single-nucleotide polymorphism data collected in nuclear families is used to localize crossovers with high spatial resolution and revealed that overall recombination hotspot usage is similar in males and females, with individual hotspots often active in both sexes.

Broad-Scale Recombination Patterns Underlying Proper Disjunction in Humans

Analysis of crossover patterns in transmissions to viable, non-trisomic offspring, using dense genotyping data collected in a large set of pedigrees, supports a requirement for one chiasma per chromosome rather than per arm to ensure proper disjunction in humans.

Age-Dependent Recombination Rates in Human Pedigrees

It is proposed that, for some chromosomes, protection against non-disjunction provided by recombination becomes less efficient with advancing maternal age, which can be partly responsible for the higher rates of aneuploidy in older women.

Fine-scale recombination rate differences between sexes, populations and individuals

This work constructs the first recombination maps based on directly observed recombinations with a resolution that is effective down to 10 kilobases (kb), and discovers novel associations between recombination characteristics of individuals and variants in the PRDM9 gene.

RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis

It is shown that mouse RNF212 is essential for crossing-over, functioning to couple chromosome synapsis to the formation of crossover-specific recombination complexes, and it is inferred that selective stabilization of key recombination proteins is a fundamental feature of meiotic crossover control.

Crossover interference in humans.

Evidence is found to support the two-pathway hypothesis in humans that the organisms that use recombination functions to achieve synapsis have two classes of crossovers, only one of which is subject to interference.

Crossover interference in the mouse.

Overwhelming evidence was found for strong positive crossover interference with average strength greater than that implied by the Carter-Falconer map function, and there was some evidence for interchromosomal variation in the level of interference.

Common and low-frequency variants associated with genome-wide recombination rate

13 variants in 8 regions that are associated with genome-wide recombination rate, 8 of which were previously unknown, are identified and are estimated to increase the male and female genetic maps by 111 and 416 cM, respectively.