Escape from X Inactivation Varies in Mouse Tissues

  title={Escape from X Inactivation Varies in Mouse Tissues},
  author={Joel B. Berletch and Wenxiu Ma and Fan Yang and Jay Shendure and William Stafford Noble and Christine M Disteche and Xinxian Deng},
  booktitle={PLoS genetics},
X chromosome inactivation (XCI) silences most genes on one X chromosome in female mammals, but some genes escape XCI. To identify escape genes in vivo and to explore molecular mechanisms that regulate this process we analyzed the allele-specific expression and chromatin structure of X-linked genes in mouse tissues and cells with skewed XCI and distinguishable alleles based on single nucleotide polymorphisms. Using a binomial model to assess allelic expression, we demonstrate a continuum between… CONTINUE READING
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