Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake

@article{Perry2006EscalationOI,
  title={Escalation of i.v. cocaine self-administration and reinstatement of cocaine-seeking behavior in rats bred for high and low saccharin intake},
  author={Jennifer L. Perry and Andrew D. Morgan and Justin J Anker and Nancy K. Dess and Marilyn Carroll},
  journal={Psychopharmacology},
  year={2006},
  volume={186},
  pages={235-245}
}
Rats selectively bred for high saccharin (HiS) intake consume more alcohol, acquire intravenous (i.v.) cocaine self-administration more rapidly, and show more dysregulated patterns of cocaine self-administration than their low saccharin-consuming (LoS) counterparts. The purpose of the present study was to determine whether HiS and LoS rats also differ in the escalation, maintenance, extinction, and reinstatement of i.v. cocaine self-administration. Two experiments were conducted in separate… CONTINUE READING

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