Escalation of cocaine self‐administration does not depend on altered cocaine‐induced nucleus accumbens dopamine levels

@article{Ahmed2003EscalationOC,
  title={Escalation of cocaine self‐administration does not depend on altered cocaine‐induced nucleus accumbens dopamine levels},
  author={Serge H. Ahmed and Daniel Lin and George F. Koob and Loren H. Parsons},
  journal={Journal of Neurochemistry},
  year={2003},
  volume={86}
}
Previous studies showed that prolonged access to cocaine or heroin self‐administration (long access, or LgA) produces an escalation in drug intake not observed with limited access to the drug (short access, or ShA). The present experiment employed in vivo microdialysis to test the role of alterations in drug pharmacokinetics and/or efficacy in increasing dopamine (DA) levels in the nucleus accumbens (NAcc) during cocaine intake escalation. In experiment 1, both ShA and LgA rats were challenged… 
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  • R. Allen
  • Psychology, Biology
    Drug and alcohol dependence
  • 2014
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