Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies.

@article{Soliz2005ErythropoietinRH,
  title={Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies.},
  author={Jorge Alberto Fuentes Soliz and Vincent Joseph and Christophe O. Soulage and Csilla Becskei and Johannes Vogel and Jean Marc Pequignot and Omolara O. Ogunshola and Max Gassmann},
  journal={The Journal of physiology},
  year={2005},
  volume={568 Pt 2},
  pages={
          559-71
        }
}
Apart from its role in elevating red blood cell number, erythropoietin (Epo) exerts protective functions in brain, retina and heart upon ischaemic injury. However, the physiological non-erythroid functions of Epo remain unclear. Here we use a transgenic mouse line (Tg21) constitutively overexpressing human Epo in brain to investigate Epo's impact on ventilation upon hypoxic exposure. Tg21 mice showed improved ventilatory response to severe acute hypoxia and moreover improved ventilatory… CONTINUE READING

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