Erythropoietin regulates endothelial progenitor cells.

  title={Erythropoietin regulates endothelial progenitor cells.},
  author={Ferdinand Hermann Bahlmann and Kirsten De Groot and Jens-Michael Spandau and Aimee L Landry and Barbara Hertel and Thorsten Duckert and Sascha M Boehm and Jan Menne and Hermann Haller and Danilo Fliser},
  volume={103 3},
Circulating bone marrow-derived endothelial progenitor cells (EPCs) promote vascular reparative processes and neoangiogenesis, and their number in peripheral blood correlates with endothelial function and cardiovascular risk. We tested the hypothesis that the cytokine erythropoietin (EPO) stimulates EPCs in humans. We studied 11 patients with renal anemia and 4 healthy subjects who received standard doses of recombinant human EPO (rhEPO). Treatment with rhEPO caused a significant mobilization… CONTINUE READING


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