Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor.

@article{Viviani2005ErythropoietinPP,
  title={Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor.},
  author={Barbara Viviani and Stefano Bartesaghi and Emanuela Corsini and Pia Villa and Pietro Ghezzi and Angela Garau and Corrado Lodovico Galli and Marina Marinovich},
  journal={Journal of neurochemistry},
  year={2005},
  volume={93 2},
  pages={412-21}
}
Erythropoietin, the principal regulator of erythroids progenitor cells, also promotes neuronal survival. Using primary cultures of rat hippocampal neurons, we investigated whether erythropoietin could mediate neuroprotection favouring the transcription of brain-derived neurotrophic factor (BDNF). Erythropoietin 2.7 nm reduced by approximately 50% the neuronal death triggered by the prototypic neurotoxicant trimethyltin (TMT) and time-dependently induced BDNF mRNA. This effect resulted in an… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 64 extracted citations

Similar Papers

Loading similar papers…