Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: role of Jak2-ERK pathway.

@article{Chan2007ErythropoietinPP,
  title={Erythropoietin protects post-ischemic hearts by preventing extracellular matrix degradation: role of Jak2-ERK pathway.},
  author={C. Chan and Y B Chen and Hsang-Hsing Lee and Ho-Shiang Huang and Y L Lai and C P Chen and M G Ma},
  journal={Life sciences},
  year={2007},
  volume={81 9},
  pages={717-23}
}
Factors predisposing to extracellular matrix degradation associated with myocardial ischemia/reperfusion (IR) usually cause cell death. Recombinant human erythropoietin (EPO) protects the myocardium from IR, but whether it affects extracellular matrix (ECM) degradation is not known. This study examined the effect of the Jak2-ERK pathway, which is triggered… CONTINUE READING