Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway.

@article{Tramontano2003ErythropoietinPC,
  title={Erythropoietin protects cardiac myocytes from hypoxia-induced apoptosis through an Akt-dependent pathway.},
  author={Anthony F Tramontano and Ranganath Muniyappa and Aislinn D Black and Mihaela C. Blendea and Inna Cohen and Lili Deng and James R. Sowers and Michael V Cutaia and Nabil El-Sherif},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={308 4},
  pages={990-4}
}
Apoptosis is a contributing cause of myocyte loss in ischemic heart disease. Recent work has shown that erythropoietin (EPO) offers protection against apoptosis in a wide variety of tissues. We demonstrate that the erythropoietin receptor (EPOR) is expressed in the neonatal rat ventricular myocyte (NRVM). Exposure of NRVMs to hypoxia, with recombinant human EPO, significantly decreased apoptosis as measured by TUNEL, flow cytometry, and caspase 3/7 like activity when compared to hypoxia… CONTINUE READING

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