Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.

@article{Calapai2000ErythropoietinPA,
  title={Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation.},
  author={Gioacchino Calapai and Maria Concetta Marciano and Francesco Corica and Alessandro Allegra and Alessandra Parisi and Nicola Frisina and Achille Patrizio Caputi and Michele Buemi},
  journal={European journal of pharmacology},
  year={2000},
  volume={401 3},
  pages={349-56}
}
Erythropoietin prevents in vitro glutamate-induced neuronal death and could play a role in the central nervous system. We investigated the in vivo effects of recombinant human erythropoietin after intraperitoneal (i.p.; 25-100 U) or intracerebroventricular (i.c.v.; 0.25-25 U) administration on survival, brain malonildialdehyde (MDA) levels, brain edema, hippocampal neuronal death and brain nitric oxide (NO) synthesis after bilateral carotid occlusion (5 min), followed by reperfusion in the… CONTINUE READING