Erythropoietin production in cultures of goat renal glomeruli.

  title={Erythropoietin production in cultures of goat renal glomeruli.},
  author={H. Burlington and Eugene P. Cronkite and U. Reincke and Esmail D. Zanjani},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={69 12},
Cultures initiated with isolated goat-kidney glomeruli produce erythropoietin over periods of 7 months. Production seems dependent upon a minimum interval of about 30 days between changes of medium. Experiments distinguishing between erythropoietin, renal activator, and serum substrate support the conclusion that the factor released to the medium of long-term glomerular cultures is erythropoietin itself. The system offers promising opportunities for studying regulation of erythropoietin… CONTINUE READING