Erythropoietin production by interstitial cells of hypoxic monkey kidneys

@article{Fisher1996ErythropoietinPB,
  title={Erythropoietin production by interstitial cells of hypoxic monkey kidneys},
  author={James W. Fisher and Stephen T. Koury and Timothy J Ducey and S Mendel},
  journal={British Journal of Haematology},
  year={1996},
  volume={95}
}
Previous studies which demonstrated that interstitial cells of the peritubular capillary bed of the kidneys are the site of erythropoietin (Epo) production have been performed in non‐primate species. In this study, kidneys from adult rhesus monkeys exposed to 18 h hypoxia (0.42 atm) with high serum (5685 mU/ml) and kidney (814 mU/g, includes serum EPO in the kidney) levels of Epo were compared with a kidney from a nonhypoxic normal rhesus monkey. Localization of Epo mRNA by in situ… Expand
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Erythropoietin is produced by tubular cells of the rat kidney
TLDR
Findings support some earlier findings that epo gene expression in response to cobalt salt stimulation of rat kidney occurs in transporting tubular epithelial cells. Expand
Erythropoietin: Physiologic and Pharmacologic Aspects
  • J. Fisher
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1997
TLDR
It has been postulated that Epo decreases the rate which Epo-dependent progenitor cells undergo programed cell death (apoptosis), and there are two major signal transduction pathways activated by the Epo receptor: the JAK2-STAT5 pathway and the ras pathway. Expand
Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis
TLDR
Novel functions ofEpo at these local sites and tissue-specific regulation of Epo production including a newly found potent regulator (estrogen) have been proposed, which rationalizes the specific functions of EpO produced by individual tissues. Expand
Developmental regulation of erythropoietin and erythropoiesis.
TLDR
Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. Expand
Developmental regulation of erythropoietin and erythropoiesis.
TLDR
Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. Expand
Erythropoietin: Physiology and Pharmacology Update 2
  • J. Fisher
  • Biology, Medicine
  • Experimental biology and medicine
  • 2003
TLDR
A novel erythropolesis-stimulating factor (NESP, darbepoetin) has been synthesized and when compared with rHu EPO, NESP has a higher carbohydrate content, a longer plasma half-life, the amino acid sequence differs from that of native human EPO at five positions, and has been reported to maintain hemoglobin levels just as effectively in patients with chronic renal failure as rHuEPO at less frequent dosing. Expand
High glucose stimulates the expression of erythropoietin in rat glomerular epithelial cells
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It is concluded that high glucose stimulates erythropoietin production and erythrooietsin receptor phosphorylation in rat glomerular epithelial cells. Expand
Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells
TLDR
Data indicate that Cd and cisplatin would induce anemia through the direct injury of the proximal renal tubular cells that are responsible for Epo production. Expand
CHAPTER 7 – Erythropoietin
This chapter deals with erythropoietin, which is the gene that is highly conserved between species. There is a 80%–82% amino acid identity between the human sequence, and that of pig, sheep, mouse,… Expand
Restoration of Haemoglobin Level Using Hydrodynamic Gene Therapy with Erythropoietin Does Not Alleviate the Disease Progression in an Anaemic Mouse Model for TGFβ1-Induced Chronic Kidney Disease
TLDR
Erythropoietin treatment in this model of chronic kidney disease normalises haemoglobin levels but has no effect on kidney fibrosis or function. Expand
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References

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TLDR
It is demonstrated that peritubular cells, most likely endothelial cells, constitute the major site of Epo production in the murine hypoxic kidney. Expand
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TLDR
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Non-radioactive in situ hybridization with a digoxigenin-labeled cRNA probe is used to localize cells that produce erythropoietin (EPO) in kidneys of anemic rats and indicates that peritubular fibroblasts are cellular sites for production of ery Anthropogenic hormone. Expand
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TLDR
It is demonstrated that hepatocytes are responsible for production of EPO in both transgenic and nontransgenic mice and that a second cell type that is similar in morphology to EPO-producing interstitial cells in the kidney also producesEPO in the livers of nontransogenic mice. Expand
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TLDR
It is suggested that hepatocytes are the major source of extrarenal erythropoietin with nonparenchymal liver cells contributing less than 1% to total hepatic erythroietin production. Expand
Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration.
TLDR
The results suggest that following an acute blood loss and during the recovery from a blood loss, the capacity to deliver oxygen, as represented by hematocrit, is the major regulator of EP production. Expand
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TLDR
In transgenic mice bearing Epo-TAg at homologous and heterologous insertion sites, renal expression was restricted to a population of cells in the interstitium of the cortex and outer medulla, and characterization shows that these are the fibroblast-like type I interstitial cells. Expand
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TLDR
In situ hybridization was used to localize the cells that produce erythropoietin (EP) in anemic murine kidneys and an uncommon, but specific type of cell was intensely labeled in the cortices of anemic kidneys. Expand
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TLDR
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