Erythropoietin production by interstitial cells of hypoxic monkey kidneys

@article{Fisher1996ErythropoietinPB,
  title={Erythropoietin production by interstitial cells of hypoxic monkey kidneys},
  author={James W. Fisher and Stephen T. Koury and Timothy J Ducey and S Mendel},
  journal={British Journal of Haematology},
  year={1996},
  volume={95}
}
Previous studies which demonstrated that interstitial cells of the peritubular capillary bed of the kidneys are the site of erythropoietin (Epo) production have been performed in non‐primate species. In this study, kidneys from adult rhesus monkeys exposed to 18 h hypoxia (0.42 atm) with high serum (5685 mU/ml) and kidney (814 mU/g, includes serum EPO in the kidney) levels of Epo were compared with a kidney from a nonhypoxic normal rhesus monkey. Localization of Epo mRNA by in situ… Expand
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  • J. Fisher
  • Biology, Medicine
  • Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1997
TLDR
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TLDR
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TLDR
Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. Expand
Developmental regulation of erythropoietin and erythropoiesis.
TLDR
Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. Expand
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  • J. Fisher
  • Biology, Medicine
  • Experimental biology and medicine
  • 2003
TLDR
A novel erythropolesis-stimulating factor (NESP, darbepoetin) has been synthesized and when compared with rHu EPO, NESP has a higher carbohydrate content, a longer plasma half-life, the amino acid sequence differs from that of native human EPO at five positions, and has been reported to maintain hemoglobin levels just as effectively in patients with chronic renal failure as rHuEPO at less frequent dosing. Expand
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CHAPTER 7 – Erythropoietin
This chapter deals with erythropoietin, which is the gene that is highly conserved between species. There is a 80%–82% amino acid identity between the human sequence, and that of pig, sheep, mouse,Expand
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Erythropoietin treatment in this model of chronic kidney disease normalises haemoglobin levels but has no effect on kidney fibrosis or function. Expand
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TLDR
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