Erythropoietin production by interstitial cells of hypoxic monkey kidneys

  title={Erythropoietin production by interstitial cells of hypoxic monkey kidneys},
  author={J. Fisher and S. Koury and T. Ducey and S. Mendel},
  journal={British Journal of Haematology},
  • J. Fisher, S. Koury, +1 author S. Mendel
  • Published 1996
  • Biology, Medicine
  • British Journal of Haematology
  • Previous studies which demonstrated that interstitial cells of the peritubular capillary bed of the kidneys are the site of erythropoietin (Epo) production have been performed in non‐primate species. In this study, kidneys from adult rhesus monkeys exposed to 18 h hypoxia (0.42 atm) with high serum (5685 mU/ml) and kidney (814 mU/g, includes serum EPO in the kidney) levels of Epo were compared with a kidney from a nonhypoxic normal rhesus monkey. Localization of Epo mRNA by in situ… CONTINUE READING
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