Erythropoietin production by a human testicular germ cell line.

  title={Erythropoietin production by a human testicular germ cell line.},
  author={Joao L. Ascensao and Franklin D. Gaylis and Duane Bronson and Elwin E. Fraley and Esmail D. Zanjani},
  volume={62 5},
An established human testis germ cell line (1411-H) was found to produce significant amounts of erythropoietin (Ep), the primary regulator of erythropoiesis. Media conditioned by the 1411-H cells stimulated erythropoiesis both in vivo and in vitro. This activity was neutralized by anti-Ep. This continuous cell line provides a unique model for the study of the mechanisms of control of Ep biogenesis.