Erythropoietin modulates the anticancer activity of chemotherapeutic drugs in a murine lung cancer model.

@article{Sigounas2004ErythropoietinMT,
  title={Erythropoietin modulates the anticancer activity of chemotherapeutic drugs in a murine lung cancer model.},
  author={George Sigounas and Sabah Sallah and Vaia Y Sigounas},
  journal={Cancer letters},
  year={2004},
  volume={214 2},
  pages={
          171-9
        }
}
In this study, we assessed the ability of erythropoietin (EPO) to synergize with various chemotherapeutic agents and suppress the growth and metastasis of solid tumors. Animals were inoculated with Lewis lung carcinoma (LLC) cells and treated with EPO alone, the designated chemotherapeutic drug (cisplatin, mitomycin C or cyclophoshamide) alone, or EPO and the drug. Tumor volume was monitored daily. Thirteen days following cell injection, tumor mass was determined. In addition, the number of the… CONTINUE READING

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