Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia.

@article{Urao2006ErythropoietinmobilizedEP,
  title={Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia.},
  author={Norifumi Urao and Mitsuhiko Okigaki and Hiroyuki Yamada and Yasushi Aadachi and Kuniharu Matsuno and Akihiro Matsui and Shinsaku Matsunaga and Kento Tateishi and Tetsuya Nomura and Tomosaburo Takahashi and Tetsuya Tatsumi and Hiroaki Matsubara},
  journal={Circulation research},
  year={2006},
  volume={98 11},
  pages={1405-13}
}
We investigated whether the mobilization of endothelial progenitor cells (EPCs) by exogenous erythropoietin (Epo) promotes the repair of injured endothelium. Recombinant human Epo was injected (1000 IU/kg for the initial 3 days) after wire injury of the femoral artery of mice. Neointimal formation was inhibited by Epo to 48% of the control (P<0.05) in an NO-dependent manner. Epo induced a 1.4-fold increase in reendothelialized area of day 14 denuded vessels, 55% of which was derived from bone… CONTINUE READING

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