Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma

@article{Lai2005ErythropoietinmediatedAO,
  title={Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma},
  author={Stephen Y Lai and Erin E. Childs and Sichuan Xi and Francesca Marietta Coppelli and W. E. Gooding and Alan Wells and Robert L Ferris and Jennifer R Grandis},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={4442-4449}
}
Originally characterized as a growth factor for erythrocytes, erythropoietin (EPO) is used to treat anemia and fatigue in cancer patients receiving radiation therapy and chemotherapy. EPO and the EPO receptor (EPOR) are expressed in nonhematopoietic cells and cancers. However, the role of EPO and EPOR within nonhematopoietic cancer cells remains incompletely understood. Although a recent clinical trial demonstrated worse tumor control and survival in head and neck cancer patients treated with… CONTINUE READING