Erythropoietin-like activity in vivo of the fusion protein rhIL-6/IL-2 (CH925).

  title={Erythropoietin-like activity in vivo of the fusion protein rhIL-6/IL-2 (CH925).},
  author={Cunyou Zhao and Peihsien Tang and Ning Mao and Shuangxi Zhang and Er-jin Fan and Bin Dong and Qiliang Li and Dewei Du},
  journal={Experimental hematology},
  volume={24 1},
CH925 is a novel cytokine of a fusion protein interleukin-6 (IL-6)/IL-2 exhibiting erythropoietin (Epo)-like effects in vivo and ex vivo, in addition to its enhanced effects compared to IL-2 and IL-6 reported by us previously, which indicates its potential clinical use. Our present study was undertaken to determine the Epo-like activity of CH925 in vivo. The reticulocyte response was observed in transfusion-induced polycythemic mice by using flow cytometry with pyronin Y staining. On day 2… CONTINUE READING