Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection

@article{King2007ErythropoietinIB,
  title={Erythropoietin is both neuroprotective and neuroregenerative following optic nerve transection},
  author={Carolyn Elizabeth King and Jennifer Rodger and Carole A Bartlett and Tammy Esmaili and Lyn Beazley},
  journal={Experimental Neurology},
  year={2007},
  volume={205},
  pages={48-55}
}
The cytokine hormone erythropoietin (EPO) is neuroprotective in models of brain injury and disease, and protects retinal ganglion cells (RGC) from cell death after axotomy. Here, we assessed EPO's neuroprotective properties in vivo by examining RGC survival and axon regeneration at 4 weeks following intraorbital optic nerve transection in adult rat. EPO was administered as a single intravitreal injection at the time of transection (5, 10, 25, 50 units, PBS control). Intravitreal EPO (5, 10… CONTINUE READING
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