Erythropoietin is both a mitogen and a survival factor.

  title={Erythropoietin is both a mitogen and a survival factor.},
  author={Jerry L. Spivak and T. Pham and Mary Ann Isaacs and W. Hankins},
  volume={77 6},
Erythropoietin (Ep) regulates the proliferation and differentiation of erythroid progenitor cells, but whether it functions solely as a survival factor or also acts as a mitogen is unresolved. Because late erythroid progenitor cells (CFU-E) are largely in cell cycle, we examined this issue by using an Ep-dependent, murine erythroleukemia cell line, HCD-57. In the presence of human Ep and fetal calf serum, HCD-57 cells had a doubling time of approximately 24 hours, and during log-phase growth… CONTINUE READING


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