Erythropoietin is both a mitogen and a survival factor.

@article{Spivak1991ErythropoietinIB,
  title={Erythropoietin is both a mitogen and a survival factor.},
  author={Jerry L. Spivak and T. Pham and Mary Ann Isaacs and W. Hankins},
  journal={Blood},
  year={1991},
  volume={77 6},
  pages={1228-33}
}
Erythropoietin (Ep) regulates the proliferation and differentiation of erythroid progenitor cells, but whether it functions solely as a survival factor or also acts as a mitogen is unresolved. Because late erythroid progenitor cells (CFU-E) are largely in cell cycle, we examined this issue by using an Ep-dependent, murine erythroleukemia cell line, HCD-57. In the presence of human Ep and fetal calf serum, HCD-57 cells had a doubling time of approximately 24 hours, and during log-phase growth… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 21 references

A survival model of erythropoietin action

  • MJ Koury, MC Bondurant
  • Science
  • 1990

Erythropoietin receptor metabolism in erythropoietindependent cell lines

  • ST Sawyer, SW Hankins
  • Blood
  • 1988

Hemin inducibility of erythropoietindependent cell lines

  • G Sigounas, H Cao, H Fox, A Schecter, WD Hankins
  • Blood
  • 1987

Isolation of erythropoietindependent cell lines suggests viability role for developmental hormones

  • WD Hankins, K Chin, R Dons, J Szabo
  • Blood
  • 1987

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