Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells.

@article{TsujiTakayama2006ErythropoietinIS,
  title={Erythropoietin induces sustained phosphorylation of STAT5 in primitive but not definitive erythrocytes generated from mouse embryonic stem cells.},
  author={Kazue Tsuji-Takayama and Takeshi Otani and Toshiya Inoue and Shuji Nakamura and Ryuichi Motoda and Masayoshi Kibata and Kunzo Orita},
  journal={Experimental hematology},
  year={2006},
  volume={34 10},
  pages={
          1323-32
        }
}
OBJECTIVE During embryonic development murine erythropoiesis occurs in two waves by producing first primitive erythroid cells (EryPs) and then definitive erythroid cells (EryDs). Erythropoietin (EPO) signaling is compared between EryPs and EryDs. METHODS We studied the EPO signaling in EryPs and EryDs using an embryonic stem-derived culture system, which can recapitulate this in vivo development process and has thus been used as a convenient in vitro model system of erythropoiesis. RESULTS… CONTINUE READING
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