Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells.


Erythropoietin is the major regulator of the proliferation and differentiation of erythroid precursors, but little is known about its molecular mechanism of action. Using a human erythroleukemic cell line (HEL), we investigated whether p21ras is involved in erythropoietin signal transduction. We found that stimulation of HEL cells with erythropoietin… (More)


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