Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts.

@article{Pinel2004ErythropoietininducedRO,
  title={Erythropoietin-induced reduction of hypoxia before and during fractionated irradiation contributes to improvement of radioresponse in human glioma xenografts.},
  author={Sophie Pinel and Muriel Barberi-Heyob and Elizabeth Moyal Cohen-Jonathan and Jean-Louis Merlin and Caroline Delmas and François Pl{\'e}nat and Pascal Chastagner},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={59 1},
  pages={250-9}
}
PURPOSE Our study investigated the influence of recombinant human erythropoietin (rHuEPO) treatment, inducing raised hemoglobin levels in nonanemic mice, on intratumor oxygenation before and during fractionated irradiation. Furthermore, the consequences of rHuEPO administration on tumor response to fractionated radiotherapy (RT) were evaluated. METHODS AND MATERIALS Experiments were performed on two human malignant glioma (GBM Nan1 and U87) xenografted in nude mice. RHuEPO was daily delivered… CONTINUE READING

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